Gastrointestinal
Gastrointestinal side effects including nausea (up to 10%), dry mouth (up to 10%), and abdominal discomfort (up to 3%) have been reported. Gastritis, salivary hypersecretion, fecal incontinence, and mouth ulceration have been reported infrequently. Aphthous stomatitis, duodenal ulcer, hiatus hernia, hyperchlorhydria, lip ulceration, reflux esophagitis, and stomatitis have been reported rarely.
General
General side effects including increased weight (up to 9%), fatigue (up to 6%), and arthralgia (3%) and have been reported. Decreased weight has been reported frequently. Edema, increased appetite, difficulty in walking, and thirst have been reported infrequently. Hyperthermia has been reported rarely.
Respiratory
Respiratory side effects including nasal congestion (up to 8%), nasopharyngitis (up to 4%), upper respiratory tract infection (up to 3%), and dyspnea (2%) have been reported. Epistaxis, asthma, rhinorrhea, sinus congestion, and nasal dryness have been reported infrequently. Dry throat, sleep apnea syndrome, and exertional dyspnea have been reported rarely.
Ocular
Ocular side effects including blurred vision (up to 3%) have been reported. Conjunctivitis (including allergic) has been reported frequently. Dry eye, blepharitis, eyelid edema, eye swelling, lenticular opacities, cataract, and hyperemia (including conjunctival) has been reported infrequently.
Musculoskeletal
Musculoskeletal side effects including musculoskeletal stiffness (up to 3%) have been reported. Myalgia and muscle spasms have been reported frequently. Torticollis has been reported rarely.
Dermatologic
Dermatologic side effects including rash (up to 3%) have been reported.
Genitourinary
Genitourinary side effects including ejaculatory failure (2%) have been reported. Erectile dysfunction has been reported frequently. Testicular pain, amenorrhea, and breast pain have been reported infrequently. Irregular menstruation, gynecomastia, menorrhagia, metrorrhagia, postmenopausal hemorrhage, and prostatitis have been reported rarely.
Psychiatric
Psychiatric side effects including restlessness, aggression, and delusion have been reported frequently. Hostility, decreased libido, paranoia, anorgasmia, confusional state, mania, catatonia, mood swings, panic attack, obsessive-compulsive disorder, bulimia nervosa, delirium, polydipsia psychogenic, impulse-control disorder, and major depression have been reported infrequently.
Renal
Renal side effects including urinary incontinence have been reported frequently. Dysuria, pollakiuria, enuresis, and nephrolithiasis have been reported infrequently. Urinary retention and acute renal failure have been reported rarely.
Metabolic
Metabolic side effects including dehydration, hypokalemia, and fluid retention have been reported infrequently.
Hematologic
Hematologic side effects including anemia, decreased hemoglobin, increased neutrophil count, decreased hematocrit, and iron deficiency anemia have been reported infrequently. Leukopenia has been reported rarely.
Endocrine
Endocrine side effects including hypothyroidism have been reported infrequently.
Hepatic
Hepatobiliary side effects including cholelithiasis have been reported infrequently.
Other
Other side effects including vertigo and tinnitus have been reported infrequently.
In normal-speak heet dat "een zombie"
Ik pas 'm wat aan.
:lol: Ach ja, je kunt niet overal goed in zijn ;)
Het is eigenlijk, naast de info, een onderstreping van een reactie door Liedetector in een andere post van me ;)
Psychiaters, met hun krankzinnige bijbel de DSM-V, doen bijna niks anders meer heden ten dagen dan voor elk denkbare mensenlijke emotie die troep voorschrijven. Gewetenloze dienaren van de Big Pharma zijn het zo geworden, met veel te veel macht ook. Zij zijn zeer goed op de hoogte van de onherstelbare en gevaarlijke schade die zij toebrengen,
Ik had nl. een tumor in het bot van mijn bovenbeen welke na een niesbui open brak waarna een stuk bot afbrak. Door die Tramadol heb ik er later niet veel pijn in gehad.
Ik gebruik zelf momenteel Tramacet, dat is tramadolhydrochloraat met paracetamol. Vanwege hevige rugpijn, elke dag, Raar spul, maar de dokters weten niet hoe ze mijn rugpijn moeten behandelen. Dat doe ik dus met behulp van een complementair genezeres.
Niks alternatief, complementair.. :) We gaan vooruit. De pijnen duren nu al meer dan drie jaar, mijn genezing neemt daardoor ook veel tijd..
Maar compos mentis ben ik altijd, ik ben de baas van mijn hersenen; de Tramadol niet.. Wat minder scherp en alert, dat wel, maar nog steeds de baas in eigen hoofd.
Dat kan je niet helemaal meer zeggen van al die andere goedjes ...
Het was mij te psychotisch
Oftewel, deze drug produceerd de psychotische waanzin waartegen het zgn voorgeschreven wordt ...
FANAPT® is licensed by Novartis Pharmaceuticals Corporation from Titan Pharmaceuticals, Inc. Je weet wel, die lui die het zo goed voor hebben met onze griep bevattelijkheid in de winter, door dubieuze vaccinaties te pushen.
Ann Fudge, a member of the Novartis board also serves on the board of directors of General Electric Co., and is a member of the board of directors of Unilever, UK/Netherlands and on the board of directors of Infosys, India. She is a trustee of the New York-based Rockefeller Foundation and the Atlanta-based Morehouse College, and is chairman of the US Programs Advisory Panel of the Bill & Melinda Gates Foundation.Fudge is also a member of the Harvard University Corporation Committee on Finance. She also is on the board of the Council on Foreign Relations.
Ach, hoe zou het ook kunnen dat er sprake zou zijn van enige belangen verstrengeling ...
Some side effects of Fanapt may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to iloperidone: oral kit, oral tablet
Get emergency medical help if you have any of these signs of an allergic reaction while taking iloperidone (the active ingredient contained in Fanapt) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking this medication and call your doctor at once if you have a serious side effect such as:
headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;
very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;
twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss);
thoughts about suicide or hurting yourself;
fever, chills, body aches, flu symptoms, sores in your mouth and throat;
seizure (convulsions);
urinating less than usual or not at all;
trouble swallowing; or
penis erection that is painful or lasts 4 hours or longer.
Less serious side effects of iloperidone may include:
dizziness, drowsiness, tired feeling;
dry mouth, stuffy nose;
breast swelling or discharge;
weight gain; or
changes in menstrual periods.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to iloperidone: oral kit, oral tablet
Nervous system
Extrapyramidal symptoms have included akathisia (up to 2.3%), bradykinesia (up to 0.6%), dyskinesia (up to 1.7%), dystonia (up to 1%), Parkinsonism (up to 0.3%), and tremor (up to 3.1%).
Nervous system side effects including dizziness (up to 20%), somnolence (up to 15%), extrapyramidal disorder (up to 5%), tremor (3%), and lethargy (up to 3%) have been reported. Paraesthesia, psychomotor hyperactivity, restlessness, amnesia, and nystagmus have been reported infrequently. Restless legs syndrome has been reported rarely.
Cardiovascular
Cardiovascular side effects including tachycardia (up to 12%), orthostatic hypotension (5%), and hypotension (3%) have been reported. Palpitations have been reported frequently. Arrhythmia, first degree atrioventricular block, cardiac failure (including both congestive and acute) have been reported rarely.
Gastrointestinal side effects including nausea (up to 10%), dry mouth (up to 10%), and abdominal discomfort (up to 3%) have been reported. Gastritis, salivary hypersecretion, fecal incontinence, and mouth ulceration have been reported infrequently. Aphthous stomatitis, duodenal ulcer, hiatus hernia, hyperchlorhydria, lip ulceration, reflux esophagitis, and stomatitis have been reported rarely.
General
General side effects including increased weight (up to 9%), fatigue (up to 6%), and arthralgia (3%) and have been reported. Decreased weight has been reported frequently. Edema, increased appetite, difficulty in walking, and thirst have been reported infrequently. Hyperthermia has been reported rarely.
Respiratory
Respiratory side effects including nasal congestion (up to 8%), nasopharyngitis (up to 4%), upper respiratory tract infection (up to 3%), and dyspnea (2%) have been reported. Epistaxis, asthma, rhinorrhea, sinus congestion, and nasal dryness have been reported infrequently. Dry throat, sleep apnea syndrome, and exertional dyspnea have been reported rarely.
Ocular
Ocular side effects including blurred vision (up to 3%) have been reported. Conjunctivitis (including allergic) has been reported frequently. Dry eye, blepharitis, eyelid edema, eye swelling, lenticular opacities, cataract, and hyperemia (including conjunctival) has been reported infrequently.
Musculoskeletal
Musculoskeletal side effects including musculoskeletal stiffness (up to 3%) have been reported. Myalgia and muscle spasms have been reported frequently. Torticollis has been reported rarely.
Dermatologic
Dermatologic side effects including rash (up to 3%) have been reported.
Genitourinary
Genitourinary side effects including ejaculatory failure (2%) have been reported. Erectile dysfunction has been reported frequently. Testicular pain, amenorrhea, and breast pain have been reported infrequently. Irregular menstruation, gynecomastia, menorrhagia, metrorrhagia, postmenopausal hemorrhage, and prostatitis have been reported rarely.
Psychiatric
Psychiatric side effects including restlessness, aggression, and delusion have been reported frequently. Hostility, decreased libido, paranoia, anorgasmia, confusional state, mania, catatonia, mood swings, panic attack, obsessive-compulsive disorder, bulimia nervosa, delirium, polydipsia psychogenic, impulse-control disorder, and major depression have been reported infrequently.
Renal
Renal side effects including urinary incontinence have been reported frequently. Dysuria, pollakiuria, enuresis, and nephrolithiasis have been reported infrequently. Urinary retention and acute renal failure have been reported rarely.
Metabolic
Metabolic side effects including dehydration, hypokalemia, and fluid retention have been reported infrequently.
Hematologic
Hematologic side effects including anemia, decreased hemoglobin, increased neutrophil count, decreased hematocrit, and iron deficiency anemia have been reported infrequently. Leukopenia has been reported rarely.
Endocrine
Endocrine side effects including hypothyroidism have been reported infrequently.
Hepatic
Hepatobiliary side effects including cholelithiasis have been reported infrequently.
Other
Other side effects including vertigo and tinnitus have been reported infrequently.
In normal-speak heet dat "een zombie"
Zoiets heet hersenspoelen, liegen, selectieve berichtgeving, huurmoordenaars. Is van alle tijden.
Het kan zijn dat men met behulp van de wetenschap hierin beter bedreven is dan vroeger.
Naar elke objectieve maatstaf gemeten moet de moderne aanpak van de psychofarmacologie - het gebruik van geneesmiddelen om van alles te behandelen, van angsten en slapeloosheid tot schizofrenie zelf - als mislukt worden beschouwd. Arthur Mandell, psychiater en dynamicus, expert in complexiteit - in de problemen van orde en chaos. San Diego.
Weinig patiënten, zo niet geen enkel zijn genezen. De meest gewelddadige uitingen van geestesziekte kunnen in de hand worden gehouden, maar niemand weet met welke gevolgen op langere termijn.
Fenothiazinen, voorgeschreven tegen schizofrenie, maken de fundamentele stoornis erger. Tricyclische antidepressiva ' verhogen de snelheid van stemmingswisselingen en leiden op de lange termijn tot hogere aantallen terugkomende psychopathologische episoden'. Enzovoort. Alleen lithium heeft medisch gezien een beetje succes, zei Mandell, en dat alleen bij enkele stoornissen.
Wat de rol van chaos in de fysiologie betreft had Mandell een interessante vraag:
'Is het mogelijk dat wiskundige pathologie, dat wil zeggen chaos, gezondheid is? En dat wiskundige gezondheid, die bestaat uit voorspelbaarheid en differentieerbaarheid van een dergelijke structuur, ziekte is?'
De gebruikelijke methoden om de instabiele , dynamische, oneindigdimensionale mens te behandelen zijn lineair en reductionistisch. Het onderliggende paradigma blijft: één gen -> één peptide -> één enzym -> één neurotransmitter -> één receptor -> één diergedrag -> één klinisch syndroom -> één geneesmiddel -> één klinische classificatieschaal. Dat domineert vrijwel al het onderzoek en elke behandeling in de psychofarmacologie.
Honderden neurotransmitters, duizenden celtypes, complexe elektromagnetische fenomenologie en continue instabiliteit liggen ten grondslag aan autonome activiteit op alle niveaus, van eiwitten tot een elektro encefalogram, maar nog steeds worden de hersenen als een chemisch één op één schakelbord beschouwd.
Aldus Mandell in het boek van James Gleick.
Waarbij mag worden opgemerkt dat er voor de rol van de gasvormige moleculen in de fysiologie van dieren (nog) geen plaats is weggelegd in zijn model. Die rol is bij geestesziektes erg belangrijk, het meest belangrijk naar mijn mening.
Vrolijke kerstdagen allemaal.
En laat je niet gek maken, want dat ben je al.
Dat weten we wel; de afbraak van synapsen en het volledig door de war gooien van functies in de hersenschors en het endocrine stelsel maakt juist dat extreem gewelddadige onvoorspelbare gedrag waartegen ze bedoeld waren. veelal onherstelbaar ook.
We weten inderdaad nu wat meer dan in 1989..
Desastreuze gevolgen.
Maar niet voor de winsten van de farmaceutische reuzen.
Aanklagen die geestesmoordenaars.. dat is mijn advies..
En nooit wat van hen kopen..
Zeg dat wel ;)